Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ Safety of Titanocenedichloride, Which mentioned a new discovery about 1271-19-8
Synthesis and reactivity against Cp2TiCl of 4-isoprenyl-beta-lactams. Trapping of N-titanoimidoyl radicals from cyanoformyl-2-azetidinones
A Staudinger reaction between methoxyketene and two different imines formed from citral afforded, after chemical transformation, the (E/Z)-4-alkenylepoxy-2-azetidinones 2, 3 and 4. These compounds, by reaction with Cp2TiCl, did not cyclize to afford the expected polycyclic beta-lactams, but the corresponding allylic alcohols 12, 13 and 15 were obtained instead. Unexpectedly, the treatment of cyanoepoxide (E)-3 with Cp2TiCl also gave the hydroxyl aldehyde (E)-14 whose formation suggests to us that a possible radical reduction of the cyano group might have occurred, and we lastly succeeded in the capture of the N-titanoimidoyl radicals. The behaviour observed for the isoprenoid side chain in the Staudinger reaction, the reactions with Cp2TiCl, as well as the trapping of N-titanoimidoyl radicals generated from benzocyanoformyl-2-azetidinones with the Ti(III) reagent, are discussed.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Safety of Titanocenedichloride, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1271-19-8
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI