A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Computed Properties of C3EuF9O9S3, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 52093-25-1, Name is Europium(III) trifluoromethanesulfonate, molecular formula is C3EuF9O9S3. In a Article, authors is Gunnlaugsson, Thorfinnur£¬once mentioned of 52093-25-1
Synthesis, structural and biological evaluation of GlyAla based lanthanide macrocyclic conjugates as supramolecular ribonuclease mimics
The glycine-alanine conjugated ligands of cyclen (1,4,7,10,-tetraazacyclododecane) 1 and 2, possessing methyl and benzyl alanine esters respectively, and the corresponding lanthanide complexes 1La, 1Eu, 1Tb, 1Yb, 2La, 2Eu, and 2Tb were designed with the aim of mimicking the nature of the hydrophobic cavity of ribonucleases. X-ray crystallographic investigations showed that 2Tb has a typical monocapped square antiprism geometry, where the Tb(III) ion is central, coordinating to the four amino moieties of the cyclen ring and four of the oxygens of amide carbonyl groups of the glycine residues of the four pendant arms, with the ninth coordinated site being occupied by a water molecule. All the complexes were shown to promote the hydrolysis of the phosphodiester bond of 2-hydroxypropyl p-nitrophenyl phosphate (HPNP, tau1/2 = 5.78 ¡Á 103 h) with 1Tb being the most efficient in promoting such hydrolysis at pH 7.4 and at 37 C for the 1Ln family with tau1/2 = 4.9 h. For the 2Ln family, 2La was most effective in promoting hydrolysis of HPNP, with tau1/2 = 3.7 h. The rate of hydrolysis was also investigated for 1La and 2La as function of pH, with both complexes displaying bell-shaped pH dependence within the physiological pH range. For 1Ln the highest activity was observed at pH 7.0, with tau1/2 = 4.6 h, whereas for 2La it occurred at pH 7.4. Beyond pH 8, the rate of both complexes was shown to be almost linearly increased. The ability of 1Eu and 2Eu to cleave a 23-mer sequence from the mRNA of the GAG-HIV gene was also investigated. It was found that both gave rise to cleavage of the sequence at every nucleotide residue after 4 h of incubations at pH 7.4 and 37 C.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 52093-25-1, help many people in the next few years.Computed Properties of C3EuF9O9S3
Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI