Reference of 4408-64-4, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 4408-64-4, name is 2,2′-(Methylazanediyl)diacetic acid. In an article，Which mentioned a new discovery about 4408-64-4
Divergent catalytic reactions provide quick access to diverse molecular scaffolds through controlled reaction pathways by tuning the catalytic conditions, especially changing auxiliary ligands and/or counterions. This study presents a computational study of Au(I)-catalyzed regiodivergent cycloisomerizations of boron-containing alkynyl epoxides toward C2- and C3-borylated furans. The calculations clarified the mechanistic details of the reaction and the regiodivergence induced by two gold catalysts. The proposed catalytic cycle involves two major stages: ring expansion of alkynyl epoxide accompanied by B(MIDA) group migration to form a m-boron furyl heterocyclic intermediate and a formal 1,2-H or a 1,2-B migration to form a C3- or C2-borylated furan. The former is identified as the bottleneck of the reaction, which proceeds via sigma activation of the oxirane moiety rather than pi activation of the alkynyl moiety proposed in experimental work, and the latter controls the regiodivergence. Calculations show that the counterion and ligand in the gold catalyst play a less important role in the ring expansion, but they are crucial for the divergent formation of borylated furans: an OTf- counterion with an (ArO)3P ligand favors the 1,2-H migration, leading to the formation of C3-borylated furan, whereas an SbF6- anion with an IPr ligand promotes the 1,2-B migration, supporting the predominant formation of C2-borylated furan. The theoretical results rationalize the observed regioselectivity and provide key insights into the mechanism of the migratory cycloisomerization of boron-containing alkynyl epoxides.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.4408-64-4. In my other articles, you can also check out more blogs about 4408-64-4
Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI