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(-)-Oudemansin (4) has been synthesized from the chiral synthon 2 obtained by microbiological asymmetric reduction of the prochiral beta-keto ester 1.Keywords – total synthesis; antibiotic; cleavage of furan; alpha-methyl beta-hydroxy ester

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Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI