62937-45-5, D-Prolinamide is a catalyst-ligand compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
62937-45-5, (R)-chloro[(1,2,3,4,5-eta)-pentamethyl-2,4-cyclopentadien-1-y 1](2-pyrrolidinecarboxamidato-kappaN1, kappaN2)iridium(III) (Cp*Ir(Cl-) (R-PA-H+)) To 40 ml of methylene chloride, 1.593 g of a pentamethylcyclopentadienyl iridium(III) chloride dimer ([Cp*IrCl2]2), 502 mg of (R)-prolinamide and 425 mg of triethylamine were successively added, and the mixture was continuously stirred at room temperature overnight. To the reaction mixture, 10 ml of a 20% aqueous sodium chloride solution was added, and the mixture was stirred for about 30 minutes and then left to stand. The resulting layers were separated. The aqueous layer was extracted with 10 ml of methylene chloride, and then the organic layers were combined and washed with 10 ml of a 20% aqueous sodium chloride solution. Further, this aqueous layer was extracted with 10 ml of methylene chloride, and then the organic layers were combined and dried over 10 g of anhydrous sodium sulfate overnight. The desiccant was filtered off and washed with methylene chloride, and then the filtrate was concentrated in vacuo. To the concentrated residue, 20 ml of tetrahydrofuran/diisopropyl ether (1/1) was added, and the mixture was stirred at 35 to 40C for about 1 hour. The precipitate was collected by suction filtration, washed with 10 ml of tetrahydrofuran/diisopropyl ether (1/1), and then dried in vacuo at 40 to 50C for 5 hours to give 1.813 g of (R)-chloro[(1,2,3,4,5-eta)-pentamethyl-2,4-cyclopentadien-1-y 1](2-pyrrolidinecarboxamidato-kappaN1, kappaN2)iridium(III) (Cp*Ir(Cl-)(R-PA-H+)) as a yellow crystalline powder. Melting point: 174.8C Elemental analysis: C15H24ClIrN2O (476.01) calculated value (%) C37.84, H5.08, N5.88, Ir40.4 found value (%) C37.81, H5.07, N5.93, Ir40.7 IR (KBr): 3429, 3282, 1599 cm-1 1H-NMR (200 MHz, CDCl3) : delta 1.60-2.28 (4H, m, 2 * CH2), 1.70 (15H, s, 5Me of Cp*), 2.71-2.93 (1H, m, one of NCH2), 3.41-3.55 (1H, m, one of NCH2), 3.89-4.01 (1H, m, NCH), 4.96 (2H, br, 2 * NH). 13C-NMR (50.3 MHz, CDCl3) : delta 9.1 (5Me of Cp*), 27.1 (CH2), 28.2 (CH2), 54.3 (NCH2), 62.9 (NCH), 84.4 (ArC of Cp*), 183.5 (C=O).
As the paragraph descriping shows that 62937-45-5 is playing an increasingly important role.
Reference£º
Patent; Hamari Chemicals, Ltd.; MAEDA, Sadayuki; SATO, Tatsunori; KAWANO, Yasuhiko; MIYAWAKI, Toshio; EP2733138; (2014); A1;,
Metal catalyst and ligand design
Ligand Template Strategies for Catalyst Encapsulation – NCBI