Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Quality Control of: Titanocenedichloride, Which mentioned a new discovery about 1271-19-8
Nine amide-functionalized titanocenyls have been synthesized and characterized by spectroscopic and analytical methods and the solid state structure of Cp(CpCO-NH-C6H4-OCF3)TiCl2 was determined by single crystal X-ray diffraction. X-ray analysis of Cp(CpCO-NH-C6H4-OCF3)TiCl2 showed that titanium is in a pseudo tetrahedral geometry and contains a Ti-O(amide) coordination. In principle, Ti-O coordination should provide more hydrolytic stability to the corresponding titanocenyls than titanocene dichloride. The cytotoxic activities of these amide-functionalized titanocenyls on HT-29 colon cancer cell line were determined by MTT assay to elucidate structure-activity relationship. All complexes were more cytotoxic than titanocene dichloride and there is no correlation between the para substituents on the phenyl ring and their cytotoxicities.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1271-19-8, help many people in the next few years.Quality Control of: Titanocenedichloride
Reference：
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI