Day: April 8, 2022

HPLC of Formula: 494-52-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Synthesis and structured N-acyl and thiourea derivatives citizine and anabazine.

This work presents the results of studies on the chem. transformation of the alkaloids mols. anabasine and cytisine to obtain their N-cinnamoyl derivatives (N-cinnamoylanabasine, N-cinnamoylcytisine), as well as possible ways for their further modification. The optimal conditions for the preparation of N-cinnamoylcytisine and N-cinnamoylanabasine in the acylation reactions of alkaloids with cinnamoyl chloride are considered. Hydrazinolysis of the resulting N-cinnamoylcytisine and N-cinnamoylanabasine was carried out. It was shown that the interaction of acrylamide derivatives of alkaloids (N-cinnamoylanabasine, N-cinnamoylcytisine) with hydrazine hydrate in ethanol leads to the formation of the corresponding pyrazole derivatives (N-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)anabasine, N-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)cytisine) resulting from the intramol. cyclocondensation of hydrazones of N-cinnamoyl derivatives By the interaction of cinnamoylisothiocyanate with the above alkaloids (anabasine, cytisine), new thiourea derivatives (N- cinnamoylaminothiocarbonylanabasine, N- cinnamoylaminothiocarbonylcytisine) are synthesized.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about A ring-expansion route to analogs of dideoxyhydantocidin, the main research direction is dideoxy hydantocidin spirocyclic nucleoside preparation; dihydrofuranyllithium addition azetidinedione; hydroxy lactam acid catalyzed rearrangement.Reference of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one.

The acid-catalyzed rearrangement of hydroxy β-lactam, formed by addition of the enantiopure dihydrofuranyllithium to N-benzyl-2,3-azetidinedione, has been investigated as a potential route to spirocyclic nucleosides.

There are many compounds similar to this compound(32780-06-6)Reference of (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-3-(Piperidin-2-yl)pyridine( cas:494-52-0 ) is researched.Electric Literature of C10H14N2.Godage, Nipunika H.; Cudjoe, Erasmus; Neupane, Rabin; Boddu, Sai HS.; Bolla, Pradeep Kumar; Renukuntla, Jwala; Gionfriddo, Emanuela published the article 《Biocompatible SPME fibers for direct monitoring of nicotine and its metabolites at ultra trace concentration in rabbit plasma following the application of smoking cessation formulations》 about this compound( cas:494-52-0 ) in Journal of Chromatography A. Keywords: biocompatible solid phase microextraction nicotine metabolite blood smoking cessation; Biocompatible SPME; Liquid chromatography-tandem mass spectrometry; Nicotine; Rabbit plasma; Smoking cessation. Let’s learn more about this compound (cas:494-52-0).

The ultra-trace determination of nicotine and its 4 major metabolites (cotinine, nornicotine, norcotinine and anabasine) from rabbit plasma was achieved by a newly developed solid phase microextraction-liquid chromatog.-tandem mass spectrometry method. Extraction of the target analytes was performed with hydrophilic/lipophilic balance-polyacrylonitrile SPME fibers. Dual fiber extraction was necessary to guarantee improved recovery at parts-per-trillion levels. Liquid chromatog. anal. was achieved in a 6-min run using a C18 (1.9μm C18, 50 mm x 2.1 mm) column with a mobile phase flow rate of 0.4 mL/min. Tandem mass spectrometry was used for detection and quantification in pos. electrospray ionization (ESI+) mode for all the targeted analytes. Two stable isotope-labeled internal standards were used for signal correction and accurate quantification. The mass spectrometer with laminar flow ion flux transport, guaranteed improved signal stability, minimal contamination of the ion guide and reproducibility into the first quadrupole analyzer. The method was validated in line with the Food and Drug Administration (FDA) guidelines for bioanal. method validation. The results met the acceptance criteria as proposed by the FDA: accuracy was tested at 0.35, 10 and 75μg L – 1 and ranged between 98.3-112.2% for nicotine, 94.1-101.9% for cotinine, 94.7-107.0% for nornicotine, 81.1-107.2% for norcotinine and 94.3-115.2% for anabasine, with precision up to 14.2%. Stability tests indicated that all the targeted analytes were stable in the desorption solution for at least 1 wk. LOQs ranged from 0.05 to 1μg L-1. The method was successfully applied to analyze plasma samples obtained from rabbits following transdermal application of a smoking cessation formulation loaded with solid lipid nanoparticles containing a nicotine-stearic acid conjugate.

There are many compounds similar to this compound(494-52-0)Electric Literature of C10H14N2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Basic copper carbonate, is researched, Molecular CH2Cu2O5, CAS is 12069-69-1, about Synergistic activation of sulfite for As(III) oxidation by basic copper(II) carbonate in homogeneous and heterogeneous processes at near-neutral conditions, the main research direction is copper carbonate arsenic catalytic oxidation density functional theory.HPLC of Formula: 12069-69-1.

Arsenic is categorized as a class I carcinogen due to its strong biol. toxicity. In this study, a novel treatment process with Cu2(OH)2CO3 as catalyst is proposed, whereby As(III) in water is oxidized by activating sulfite to generate SO4·- and SO4·- radicals. Under conditions of [Cu2(OH)2CO3]0 = 0.01 g·L-1, [sulfite]0 = 0.3 mmol·L-1, and initial pH 8.0, 94% of As(III) was converted into As(V) within 20 min, whereby dissolved oxygen had a pivotal impact on the reaction. However, HCO3-, humic acid, and fulvic acid all significantly inhibited the oxidation Heterogeneous electron transfer on the catalyst surface and homogeneous dissolved Cu2+ jointly activated sulfite in the Cu2(OH)2CO3/sulfite system, with the heterogeneous process predominating. D. functional theory (DFT) calculations disclose a dominate phys. adsorption of sulfite on Cu2(OH)2CO3 surface with 1.74 electrons transferred. >90% of As(III) was still oxidized after recycling the material five times, indicating excellent reusability. Overall, it shows good potential for application in the removal of As(III) from real water samples.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Investigation of the possible pharmacologically active forms of the nicotinic acetylcholine receptor agonist anabaseine, the main research direction is nicotinic acetylcholine receptor agonist anabaseine pharmacol active form; acetylcholine; alkaloid; anabaseine; bipyridyl; cholinergic; nicotine; nicotinic acetylcholine receptor; ring-chain tautomerism; toxin.Electric Literature of C10H14N2.

Three major forms of the nicotinic agonist toxin anabaseine (cyclic iminium, cyclic imine and the monocationic open-chain ammonium-ketone) co-exist in almost equal concentrations at physiol. pH. We asked the question: Which of these forms is pharmacol. active. First, we investigated the pH dependence of anabaseine inhibition of [3H]-methylcarbamylcholine binding at rat brain α4β2 nicotinic acetylcholine receptors (nAChRs). These experiments indicated that one or both monocationic forms interact with the orthosteric binding site for ACh. However, since they occur at equal concentrations near physiol. pH, we employed another approach, preparing a stable analog of each form and examining its agonist activities and binding affinities at several vertebrate brain and neuromuscular nAChRs. Only 2-(3-pyridyl)-1,4,5,6-tetrahydropyrimidine monohydrogen chloride (PTHP), the cyclic iminium analog, displayed nAChR potencies and binding affinities similar to anabaseine. The cyclic imine analog 2,3′-bipyridyl and the open-chain ammonium-ketone analog 5-methylamino-1-(3-pyridyl)-1-pentanone (MAPP), displayed ≤1% of the activity predicted if the one form was solely active. The lower potency of weakly basic 2,3′-bipyridyl can be explained by the presence of a small concentration of its monocationic form. Since the open chain ammonium-ketone monocationic form of anabaseine has some structural similarity to the neurotransmitter GABA, we also tested the ability of anabaseine and its 1,2-dehydropyrrolidinyl analog myosmine to activate a mammalian GABAA receptor, but no activity was detected. We conclude that the monocationic cyclic iminium is the form which avidly binds and activates vertebrate nAChRs.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Safety of 11-Bromoundecanoic acid. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Effect of different frying methods on flavor quality of pork chops. Author is Meng, Xiangren; Chen, Shengshu; Chen, Chang; Wang, Hengpeng; Wu, Peng; Tu, Mingliang; Gao, Ziwu.

In this paper, pork chops were used as research objects to analyze the effects of different frying methods (traditional, microwave, air fryer) on lipid oxidation and volatile flavor components. The results showed that the frying could promote the fat oxidation of pork. The oxidation value (POV) and thiobarbituric acid value (TBARS) of the pork chops were significantly increased after different frying methods (P<0.05). There was a significant difference in the degree of lipid oxidation between the pork chops of different frying methods (P<0.05). Among them, the microwave fried pork chops had the highest degree of lipid oxidation, followed by the air fryer, while the traditional fried samples had the lowest oxidation degree. In the traditional fried, microwave fried and air fryer fried pork chops samples, 54, 50, 53 kinds of volatile flavor substances were detected, among which the aldehydes were the main volatile components. There was no significant (P<0.05) difference in the relative content of total aldehydes among the three frying methods. Results: indicating that the air fryer had a high similarity to the traditional and microwave frying in the flavor quality of the pork chops. 2, 3-dimethylpyrazine having a baking aroma was detected in a sample of fried pork chops in the air fryer. I hope my short article helps more people learn about this compound(11-Bromoundecanoic acid)Safety of 11-Bromoundecanoic acid. Apart from the compound(2834-05-1), you can read my other articles to know other related compounds.

Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

COA of Formula: C10H14N2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Comparison of cigarette, little cigar, and waterpipe tobacco smoke condensate and e-cigarette aerosol condensate in a self-administration model. Author is Marusich, Julie A.; Wiley, Jenny L.; Silinski, Melanie A. R.; Thomas, Brian F.; Meredith, Steven E.; Gahl, Robert F.; Jackson, Kia J..

This study evaluated the reinforcing effects of aqueous solutions of smoke/aerosol condensate from cigarettes, little cigars, electronic cigarettes (e-cigarettes), and waterpipe tobacco in a self-administration procedure to determine if abuse liability of these tobacco products differed. Following nicotine dose-effect assessment (1, 7.5, 15, and 30μg/kg/infusion), rats were given access to smoke/aerosol condensate derived from their assigned tobacco product. Rats responded for smoke/aerosol condensate containing 1, 7.5, 15, and 30μg/kg/infusion nicotine, with the ratio of nicotine:non-nicotine constituents held constant across doses for each tobacco product. Responding for nicotine or smoke/aerosol condensate was also assessed on a progressive ratio schedule of reinforcement. Cigarette, little cigar, and e-cigarette smoke/aerosol condensates shifted the nicotine dose-effect curve leftward, whereas waterpipe tobacco smoke condensate shifted the dose-effect curve rightward. Smoke/aerosol condensate from all tobacco products produced similar levels of responding compared to nicotine alone during the progressive ratio phase. Results suggest that non-nicotine constituents in cigarettes, little cigars, and e-cigarettes differentially enhance nicotine’s reinforcing potency. In contrast, waterpipe tobacco blunted nicotine’s reinforcing potency, suggesting that it may contain unique constituents that dampen nicotine’s reinforcing effects.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Reference of (S)-3-(Piperidin-2-yl)pyridine. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Long-term trends in tobacco use assessed by wastewater-based epidemiology and its relationship with consumption of nicotine containing products. Author is Zheng, Qiuda; Gartner, Coral; Tscharke, Benjamin J.; O’Brien, Jake W.; Gao, Jianfa; Ahmed, Fahad; Thomas, Kevin V.; Mueller, Jochen F.; Thai, Phong K..

Measurement of population tobacco use via wastewater-based epidemiol. (WBE) provides objective data to evaluate the efficacy of tobacco control strategies. However, current WBE tobacco-use estimates based on nicotine metabolites (cotinine and hydroxycotinine) can be masked by use of non-tobacco nicotine-containing products. To better understand nicotine and tobacco use, we analyzed tobacco-specific biomarkers, anabasine and anatabine, as well as nicotine metabolites, cotinine and hydroxycotinine, in wastewater samples collected for 6 wk per yr over 6 years (2012-2017) from an Australian wastewater treatment plant serving approx. 100,000 people. Significant annual declines were observed for anabasine, anatabine, cotinine and hydroxycotinine of -3.0%, -2.7%, -2.4%, and -2.1%, resp. The results corresponded with the annual declining trends reported from surveys (-5%) and taxation statistics (-4%). Significant annual decreases in the ratios of anabasine to cotinine (-1.2%) and anatabine to cotinine (-1.0%) suggested a relative increase in the use of non-tobacco nicotine products at the same time that tobacco use was declining. Monitoring tobacco use with anabasine and anatabine removed influence from nicotine-containing products, showing larger reductions in this Australian city than via nicotine biomarkers, while also demonstrating their suitability for monitoring long-term trends.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of C11H21BrO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Redox Control of Particle Deposition from Drying Drops. Author is Galy, Pauline E.; Guitton-Spassky, Tiffany; Sella, Catherine; Thouin, Laurent; Vitale, Maxime R.; Baigl, Damien.

The coffee-ring effect (CRE), which denotes the accumulation of nonvolatile compounds at the periphery of a pinned sessile drying drop, is a universal and ubiquitous yet complex phenomenon. It is crucial to better understand and control it, either to avoid its various deleterious consequences in many processes requiring homogeneous deposition or to exploit it for applications ranging from controlled particle patterning to low cost diagnostics. Here, we report for the first time the use of a reduction-oxidation (redox) stimulus to cancel the CRE or harness it, leading to a robust and tunable control of particle deposition in drying sessile drops. This is achieved by implementing redox-sensitive ferrocenyl cationic surfactants of different chain lengths in drying drops containing anionic colloids. Varying surfactant hydrophobicity, concentration, and redox state allows us not only to control the overall distribution of deposited particles, including the possibility to fully cancel the CRE, but also to modify the microscopic organization of particles inside the deposit. Notably, with all other parameters being fixed, this method allows the adjustment of the deposited particle patterns, from polycrystalline rings to uniform disks, as a function of the oxidation rate. We show that the redox control can be achieved either chem. by the addition of oxidants or electrochem. by applying a potential for additive-free and reversible actuation in a closed system. This correlation between the redox state and the particle pattern opens a perspective for both redox-programmable particle patterning and original diagnostic applications based on the visual determination of a redox state. It also contributes to clarify the role of surfactant charge and its amphiphilic character in directing particle deposition from drying suspensions.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3393-45-1, is researched, Molecular C5H6O2, about Visible-light-driven radical 1,3-addition of selenosulfonates to vinyldiazo compounds, the main research direction is selenosulfonate alkenyl diazoacetate regioselective diastereoselective selenosulfonylation green chem; seleno allylic sulfone green preparation.Synthetic Route of C5H6O2.

Herein, the authors report a visible light-driven radical 1,3-selenosulfonylation of vinyldiazo compounds with selenosulfonates, providing various γ-seleno allylic sulfones in good yields. This photochem. reaction was carried out at room temperature in an open flask using Et acetate as the solvent without any photocatalysts or additives. The control experiments corroborated that the 1,3-addition proceeded via a radical-chain propagation process. The synthetic applications of the resulting products were demonstrated by deselenization, reduction, bromination and allylation.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI