Day: April 8, 2022

Product Details of 2834-05-1. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Electroinduced Reconfiguration of Complex Emulsions for Fabrication of Polymer Particles with Tunable Morphology. Author is Guo, Yongshun; Fang, Yanxiong; Jia, Kangle; Yu, Yue; Yu, Longfei; Li, Huanling; Zhang, Junjie; Zheng, Xiaoshan; Huang, Linjia; Wen, Wu; Mai, Yuliang.

Continuous morphol. control of anisotropic particles is always an important challenge in the field of materials. In this study, a new strategy for continuous fabrication of polymer particles with various morphologies induced by electricity is reported using complex emulsions as template. A synthetic electro-responsive surfactant containing ferrocene group is used to prepare complex emulsions, which contain a polymerizable monomer as inner phase. With the increasing time of elec. stimulation on the complex emulsions, hollow, hemispherical, mushroom-like, and spherical particles are constructed successively after photopolymerization The Marangoni effect caused by the heterogeneity in the interfacial tension at the droplet surface is the reason for the reconfigurable morphol. of the complex emulsion. The controllable complex emulsions by electricity present a versatile platform for constructing fine control of the microstructure and shape anisotropy of particles having customized shapes and functionalities, opening a new possibility for designing sophisticated architectures.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 89972-77-0, is researched, SMILESS is CC1=CC=C(C2=CC(C3=NC=CC=C3)=NC(C4=NC=CC=C4)=C2)C=C1, Molecular C22H17N3Journal, Journal of Coordination Chemistry called Synthesis, spectroscopy, thermal behavior, and X-ray crystal structure of two lead(II) complexes with 4′-(4-tolyl)-2,2′;6′,2”-terpyridine (ttpy), Author is Saghatforoush, Lotfali; Adil, Karim; Sahin, Ertan; Babaei, Somayyeh; Musevi, Seyid Javad, the main research direction is preparation acetate bridged dimeric lead tolylterpyridine complex; crystal structure acetate bridged dimeric lead tolylterpyridine complex; cyclic voltammetry acetate bridged dimeric lead tolylterpyridine complex.COA of Formula: C22H17N3.

Two new dimeric Pb(II) complexes with 4′-(4-tolyl)-2,2′;6′,2”-terpyridine (ttpy), [Pb(ttpy)(μ-AcO)]2(PF6)2 (1) and [Pb(ttpy)(μ-AcO)I]2 (2), were synthesized and characterized by CHN elemental anal., 1H NMR, 13C NMR, IR spectroscopy, and structurally analyzed by x-ray single-crystal diffraction. The thermal stability of these compounds was studied by TGA and DTA. Single crystal x-ray anal. shows that 1 and 2 are dimeric units with Pb-(μ-AcO)2-Pb-type bridging, and the coordination number in 1 is six and in 2 is seven. The arrangement of donors suggests a gap in the coordination geometry around lead, possibly occupied by stereo-active lone pair of electrons on Pb(II), so the coordination sphere is hemidirected. Also, dimeric units are connected by a network of hydrogen bonds and π-π stacking as well. Electrochem. properties of free ligand and complexes were studied in the presence of tetra-Bu ammonium perchlorate as supporting electrolyte and by using a glassy carbon electrode. Both lead complexes show irreversible Pb(II) oxidation Cyclic voltammetry indicates that these processes are diffusion-controlled. The data from electrochem. studies show that the total limiting current of each of the studied complexes corresponds to two-electron transfer.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Temple, Kayla J.; Engers, Julie L.; Long, Madeline F.; Gregro, Alison R.; Watson, Katherine J.; Chang, Sichen; Jenkins, Matthew T.; Luscombe, Vincent B.; Rodriguez, Alice L.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W. researched the compound: 4-Bromo-2,5-dichloropyridine( cas:1184917-16-5 ).Quality Control of 4-Bromo-2,5-dichloropyridine.They published the article 《Discovery of a novel 3,4-dimethylcinnoline carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping》 about this compound( cas:1184917-16-5 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: muscarinic acetylcholine receptor M4 pos allosteric modulator SAR; M(4); Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Structure activity relationship (SAR). We’ll tell you more about this compound (cas:1184917-16-5).

This Letter details our efforts to replace the 2,4-dimethylquinoline carboxamide core of our previous M4 PAM series, which suffered from high predicted hepatic clearance and protein binding. A scaffold hopping exercise identified a novel 3,4-dimethylcinnoline carboxamide core that provided good M4 PAM activity and improved clearance and protein binding profiles.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Related Products of 494-52-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (S)-3-(Piperidin-2-yl)pyridine, is researched, Molecular C10H14N2, CAS is 494-52-0, about Determination of nicotine-related impurities in nicotine pouches and tobacco-containing products by liquid chromatography-tandem mass spectrometry. Author is Avagyan, Rozanna; Spasova, Maya; Lindholm, Johan.

Smokeless tobacco products and nicotine-containing tobacco-free oral pouches have increased in popularity in recent years. They are associated with far fewer health hazards compared to cigarettes. Nicotine pouches are filled with non-tobacco filler and nicotine. The nicotine used in nicotine pouches usually comes from the extraction of tobacco; thus, related alkaloids may be found as impurities at low levels. Moreover, nicotine degradation products are formed because of microbial action, flavor oxidation, exposure to high temperatures, etc. Currently, there are no published or recommended methods for the anal. of nicotine degradants in nicotine pouches. Here, we present a sensitive and selective liquid chromatog.-tandem mass spectrometry method for the simultaneous determination of seven nicotine-related impurities. All seven analytes and corresponding deuterated internal standards were separated within 3.5 min, including 1 min equilibration. The method was fully validated, showing good linearity with correlation coefficients >0.996 for all analytes, good extraction yields ranging from 78% to 110%, limits of detection between 0.08 and 0.56 μg/g and limits of quantification between 0.27 and 2.04 μg/g. Although the method was mainly developed to determine the degradants of nicotine in nicotine pouches, it was validated and performed well on a broader range of tobacco-containing products.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 494-52-0, is researched, SMILESS is C1(C=NC=CC=1)[C@@H]1CCCCN1, Molecular C10H14N2Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Drug and Alcohol Dependence called Route of administration effects on nicotine discrimination in female and male mice, Author is Lefever, Timothy W.; Thomas, Brian F.; Kovach, Alexander L.; Snyder, Rodney W.; Wiley, Jenny L., the main research direction is Nicotine route of administration behavior; Discrimination; Nicotine; Route of administration; Sex differences.Synthetic Route of C10H14N2.

To provide preclin. models of vaping that incorporate olfactory cues and chemosensory effects (including flavors) that play a role in human vaping behavior, the feasibility of using a modified e-cigarette device for delivery of aerosolized nicotine was examined in a nicotine discrimination procedure in mice. After determination of a s.c. nicotine dose-effect curve, aerosolized freebase nicotine and nicotine-containing tobacco products (i.e., non-flavored and Arctic Blast e-liquids) were evaluated. Nicotine dose-dependently substituted in mice of both sexes, although females showed less sensitivity and greater variability. By contrast, aerosolized nicotine, regardless of formulation, produced concentration-dependent increases up to maximum of 46-62% nicotine-associated responding. Brain nicotine concentrations for each sex were similar for s.c. 0.75 mg/kg nicotine and 30 mg/mL freebase nicotine. Mice of both sexes readily acquired s.c. nicotine discrimination, but females showed less sensitivity. Further, all three formulations of aerosolized nicotine produced increases in nicotine-like responding in mice of each sex. However, the maximum magnitude of these increases did not engender a similar degree of substitution as s.c. 0.75 mg/kg nicotine, despite similar brain concentrations of nicotine at 30 mg/mL aerosolized nicotine. Addnl. research is needed for determination of the reason(s); however, results here demonstrate initial feasibility for examination of the discriminative stimulus effects of vaped drugs such as nicotine.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Name: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Two approaches to the enantioselective synthesis of (4R)-(-)-4-hydroxymethyl-4-thiobutyro-1,4-lactone. Author is Zunszain, Patricia A.; Varela, Oscar.

Enantiomerically pure (4R)-4-hydroxymethyl-4-thiobutyro-1,4-lactone [(5R)-dihydro-5-(hydroxymethyl)-2(3H)-thiophenone (I)] and derivatives were synthesized by two enantiospecific sequences employing D-ribono-1,4-lactone (II) and L-glutamic acid (III) as chiral templates. The key step in the first approach was the SmI2-promoted 2,3-deoxygenation of a 4-thio-L-lyxono-1,4-lactone derivative, prepared from II. The other strategy, which starts from III, involves the (5S)-dihydro-5-(p-tolylsulfonyloxymethyl)-2-(3H)-furanone (IV) as chiral precursor. This was converted into a 4,5-thiirane derivative via the corresponding 4,5-epoxide. Regioselective opening of the thiirane ring by acetate followed by O-deacetylation gave I (40% overall yield from IV).

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein, the main research direction is esophageal cancer AML SHP2 PROTAC degrader ERK inhibition phosphorylation.Safety of 11-Bromoundecanoic acid.

Src homol. 2 domain-containing phosphatase 2 (SHP2) is an attractive therapeutic target for human cancers and other human diseases. Herein, we report our discovery of potent small-mol. SHP2 degraders whose design is based upon the proteolysis-targeting chimera (PROTAC) concept. This work has led to the discovery of potent and effective SHP2 degraders, exemplified by SHP2-D26. SHP2-D26(I) achieves DC50 values of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4;11 cells, resp., and is capable of reducing SHP2 protein levels by >95% in cancer cells. SHP2-D26 is >30-times more potent in inhibition of phosphorylation of extracellular signal-regulated kinase (ERK) and of cell growth than SHP099, a potent SHP2 inhibitor, in KYSE520 and MV4;11 cancer cell lines. This study demonstrates that induced SHP2 degradation is a very effective approach to inhibit the function of SHP2. Further optimization of these SHP2 degraders may lead to the development of a new class of therapies for cancers and other human diseases.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Application In Synthesis of 11-Bromoundecanoic acid. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 11-Bromoundecanoic acid, is researched, Molecular C11H21BrO2, CAS is 2834-05-1, about pH-Responsive Behavior of Pickering Emulsions Stabilized by a Selenium-Containing Surfactant and Alumina Nanoparticles. Author is Yu, Shijie; Lv, Miao; Lu, Guoping; Cai, Chun; Jiang, Jianzhong; Cui, Zhenggang.

Herein, we describe pH-responsive Pickering emulsions stabilized by a sodium carboxylate-derived selenium surfactant (C10-Se-C10·(COONa)2) in combination with pos. charged alumina nanoparticles. Unlike other bola-type carboxylate surfactants (e.g., disodium eicosanoate), C10-Se-C10·(COONa)2 is soluble in water with a low Krafft temperature (36.1 °C). The emulsions are sensitive to pH variations, and efficient demulsification can be achieved by a pH trigger. The carboxylic sodium group in the C10-Se-C10·(COONa)2 structure can be reversibly cycled between its anionic and nonionic states (carboxylic acid), resulting in a pH-controlled electrostatic attraction between the surfactant and alumina. The Pickering emulsion can be reversibly switched between “”on”” (stable) and “”off”” (unstable) states by pH at least four times. Compared with the emulsions stabilized by specially synthesized stimuli-responsive particles or surfactants, the method reported here is much easier to implement and requires very low concentrations of the surfactant and nanoparticles, with potential applications in the fields of biomedicine, drug delivery, and cosmetics.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (S)-3-(Piperidin-2-yl)pyridine(SMILESS: C1(C=NC=CC=1)[C@@H]1CCCCN1,cas:494-52-0) is researched.COA of Formula: C5H8O3. The article 《Simultaneous determination of multiple components in cigarettes by mechanochemical extraction and direct analysis in real time mass spectrometry in minutes》 in relation to this compound, is published in Analytica Chimica Acta. Let’s take a look at the latest research on this compound (cas:494-52-0).

A simple, rapid and high throughput anal. approach with combination of mechanochem. extraction (MCE) and direct anal. in real time mass spectrometry (DART-MS) anal. was developed for the simultaneous determination of multiple chem. components in cigarette fillers. Different kinds of substances including nicotine, cigarette alkaloids, carbohydrates, organic acids, humectants and other additives were successfully extracted using MCE and detected by high resolution DART-MS. Six solvents of various polarities were compared during MCE process and significant differences were observed Different brands of cigarettes as well as standard research cigarette exhibited distinctive chem. features and DART-MS fingerprints. Principle component anal. showed clear differentiation among different cigarettes extracted with the same solvent and different solvent extracts of the same type of cigarette. The putative chem. formulas were proposed based on accurate m/z values with <10 ppm mass Errors. The relative contents of nicotine and other identified substances were compared and significant differences were observed among cigarettes of different locations. The whole procedure of MCE combined with DART-MS only takes minutes from raw cigarette fillers to obtaining the semi-quant. results. The operation is simple and high throughput, providing an efficient method to analyze cigarette composition, and to establish a methodol. to acquire the rapid cigarette fingerprints for quality control. There are many compounds similar to this compound(494-52-0)Reference of (S)-3-(Piperidin-2-yl)pyridine. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

COA of Formula: C5H8O3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one, is researched, Molecular C5H8O3, CAS is 32780-06-6, about Chirospecific synthesis of (S)-(+)- and (R)-(-)-5-amino-4-hydroxypentanoic acid from L- and D-glutamic acid via (S)-(+)- and (R)-(-)-5-hydroxy-2-oxopiperidine. Author is Herdeis, C..

(S)-H2NCH2CH(OH)CH2CH2CO2H [(S)-I] was prepared stereospecifically from L-glutamic acid in 6 steps. Thus, L-glutamic acid was converted to lactone II (R = CO2H), which was reduced by H3B.S(Me)2 to give II (R = CH2OH), which was O-mesylated and then treated with NaN3 to give II (R = CH2N3). The latter was hydrogenated over Pd/C to give piperidine III, which was cleaved by aqueous Ba(OH)2 to give (S)-I. (R)-I was prepared analogously from D-glutamic acid.

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Reference:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI