Day: March 10, 2021

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ Recommanded Product: (1R,2R)-Cyclohexane-1,2-diamine, Which mentioned a new discovery about 20439-47-8

Structure and asymmetric epoxidation reactivity of chiral Mn(III) salen catalysts modified by different axial anions

A series of chiral Mn(iii) catalysts [salen-Mn(iii)][X] (X- = Cl-, OAc-, NO3-, BF4-, CF3SO3-, OCH2CH3-) were synthesized by ion exchange. The influence of the axial anion on both the electronic structure and steric configuration of [salen-Mn(iii)][X] were carefully investigated. Besides, the reactivity and enantioselectivity of these catalysts were explored in the asymmetric epoxidation of olefins. The obtained results indicate that the axial anions have influences on both electronic structure and steric configuration of the chiral Mn(iii) salen complexes. Controlling the reactivity and enantioselectivity of these chiral Mn(iii) salen complexes can be achieved by changing the axial anions.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is traditionally divided into organic and inorganic chemistry. Computed Properties of C6H11NO2. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 3105-95-1

PROCESS FOR PRODUCING PIPECOLAMIDE DERIVATIVE

A method of manufacturing a pipecolamide derivative, characterized in that pipecolic acid or an acid salt thereof is reacted with an amine in an inert solvent in the presence of a condensing agent such as dicyclohexylcarbodiimide, 1-ethyl- 2-(2-dimethylaminopropyl) carbodiimide, methanesulfonyl chloride or phosphoryl chloride. Pipecolamide derivatives, particularly in optically active forms thereof can be efficiently and economically manufactured without harmful gas by-products.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ Quality Control of: (R)-[1,1′-Binaphthalene]-2,2′-diol, Which mentioned a new discovery about 18531-94-7

Novel P,N ligands derived from (R)- and (S)-1-phenylethylamine with (2R,5R)-2,5-dimethylphospholanyl groups (DuPHAMIN) for asymmetric catalysis

Novel P,N chelating ligands with three stereogenic centres in positions alpha to the donor atoms have been prepared in good yields and high enantiomeric purity by a series of reactions beginning with either (R)- or (S)-1-phenylethylamine. These isomers were first lithiated with tBuLi and converted into aminophosphanes 3a by treatment with (Et2N)2PCl. They were transformed into the enantiomeric primary phosphanes 4 by quantitative solvolysis with ethanol to give the phosphonous acid esters 3b and subsequent reduction with LiA1H4. Stepwise treatment of 4 with nBuLi and the cyclic sulfate of (S,S)-2,5-hexanediol gave the isomeric tertiary phosphanes (R, RR)-5 and (S, RR)-5. Treatment of the aminophosphane (R)-3a with (R)-2,2?-binaphthol yielded the aminophosphonite (R,R)-6 in high yields. Cationic (COD)Rh complexes of 5 were prepared by treatment with [Rh(COD)Cl]2, the PF6- salts 7a being isolated. Analogous (2,5-norbornadiene)Rh complexes 7b were prepared similarly. The chelate nature of the P,N ligands in these salts is indicated by their NMR spectra in solution and is confirmed by the crystal structures of (R,RR)-7a and (S,RR)-7a. With the exception of (S,RR)-7a, the complexes 7a and 7b are shown to catalyse the asymmetric hydrogenation of methyl acetamidocinnamate at room temperature. Differences in the catalytic activity of the complexes are related to the different dynamic behaviour detected by the 1H EXSY spectra for the COD ligands of 7a. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 112068-01-6, molcular formula is C17H19NO, introducing its new discovery. category: catalyst-ligand

Modular synthesis of cyclic cis- and trans-1,2-diamine derivatives

Structurally diverse carbocycles with two vicinal nitrogen-substituents were prepared in expedient three-component reactions from simple amines, aldehydes, and nitroalkenes. trans,trans-6-Nitrocyclohex-2-enyl amines were obtained in a one-pot domino reaction involving condensation, tautomerisation, conjugate addition, and nitro-Mannich cyclisation. Upon employment of less nucleophilic carboxamides, a concerted Diels-Alder cycloaddition mechanism operated to give the corresponding cis,trans-nitrocyclohexenyl amides. Both types of substituted carbocycles offer ample opportunities for chemical manipulations at the core and periphery. Ring oxidation with MnO2 affords substituted nitroarenes. Reduction with Zn/HCl provides access to various trans- and cis-diaminocyclohexenes, respectively, in a straight-forward manner. With enantiopure secondary amines, a two-step synthesis of chiral nitrocyclohexadienes was developed (82-94% ee).

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, SDS of cas: 20439-47-8, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 20439-47-8, Name is (1R,2R)-Cyclohexane-1,2-diamine, molecular formula is C6H14N2. In a Article, authors is Cai, Pengfei£¬once mentioned of 20439-47-8

Facile enantioseparation and recognition of mandelic acid and its derivatives in self-assembly interaction with chiral ionic liquids

Mandelic acid and its derivatives are important medical intermediates in the pharmaceutical industry. Different stereoisomers exhibited distinct biological properties to human bodies. Given that, enantioselective recognition and separation of mandelic acid are of great importance. In this study, four novel different types of chiral ionic liquids bearing designed functional groups were synthesized and successful enantioselective precipitation with mandelic acid and its derivatives. That is, (R, R)-chiral ionic liquid 1 can coprecipitated with S-mandelic acid and its derivatives was observed. In addition, good correlation coefficient is achieved by using electrospray mass spectrum at negative ion pattern for quick analysis of the enantioselective precipitation, which could be served as a method of enantioselective recognition. The possible intermolecular interactions are established after systematical studies by NMR spectroscopy and DFT calculations.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ SDS of cas: 68737-65-5, Which mentioned a new discovery about 68737-65-5

Enantioselective Synthesis of beta-Quaternary Carbon-Containing Chromanes and 3,4-Dihydropyrans via Cu-Catalyzed Intramolecular C-O Bond Formation

A copper-catalyzed efficient enantioselective construction of chiral quaternary carbon-containing chromanes and 3,4-dihydropyrans is reported. The desymmetric C-O coupling is enabled by a chiral dimethylcyclohexane-1,2-diamine ligand and provides the desired products in good yields with high enantioselectivities. This method presents a broad substrate scope and is applicable to diversely substituted aryl bromides and alkenyl bromides. The application is demonstrated by a gram-scale synthesis and derivatization of the products toward valuable building blocks.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Electric Literature of 20439-47-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.20439-47-8, Name is (1R,2R)-Cyclohexane-1,2-diamine, molecular formula is C6H14N2. In a Article£¬once mentioned of 20439-47-8

When is an imine not an imine? Unusual reactivity of a series of Cu(ii) imine-pyridine complexes and their exploitation for the Henry reaction

In this paper we report the synthesis and solid-state structures for a series of pyridine based Cu(ii) complexes and preliminary data for the asymmetric Henry reaction. Interestingly, the solid-state structures indicate the incorporation of an alcohol into one of the imine groups of the ligand, forming a rare alpha-amino ether group. The complexes have been studied via single crystal X-ray diffraction, EPR spectroscopy and mass spectrometry. Intriguingly, it has been observed that the alcohol only adds to one of the imine moieties. Density functional theory (DFT) calculations have also been employed to rationalise the observed structures. The Cu(ii) complexes have been tested in the asymmetric Henry reaction (benzaldehyde + nitromethane or nitroethane) with ee’s up to 84% being achieved as well as high conversions and modest diastereoselectivities. The Royal Society of Chemistry 2011.

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Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Synthetic Route of 57709-61-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.57709-61-2, Name is 1,10-Phenanthroline-2,9-dicarboxylic acid, molecular formula is C14H8N2O4. In a article£¬once mentioned of 57709-61-2

Highly Selective Sensing of Cd(II) Ion by Hexanuclear Functionalized Zn(II) Cluster

The organic ligand 1,10-phenanthroline-2,9-dicarboxylic acid (H2L) was used to react with ZnSO4¡¤7H2O at 140?C for two days to obtain the complex [Zn6(L)6(H2SO4)]¡¤3CH3CN¡¤Et3N (1). The structure of complex is confirmed by X-ray crystallography, TG and PXRD. The structure suggested that six ligands chelated with six Zn2+ ions. Every five-coordinated Zn(II) ion is surrounded by two N atoms and three O atoms (one sulfate radical or three ligands) with the N2O3 coordination environment. Each Zn(II) ion in the structure of complex 1 binds only one L2? ligand. The metal center Zn2 and Zn3 are bridged by SO4 2?. The photoluminescence of complex 1 is obvious. Moreover, in the presence of Cd2+ ions, the complex exhibits an efficient recognition ability, and it realizes the recognition of toxic metal ions.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ category: catalyst-ligand, Which mentioned a new discovery about 848821-76-1

Inhibitors of phosphodiesterase type 5A for treating or preventing muscle disease or the symptoms thereof in a patient

Disclosed are pharmaceutical compositions and methods for treating or preventing muscle diseases or the symptoms thereof. The compositions typically include and the methods typically utilize phosphodiesterase type 5A inhibitors.

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Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI

Electric Literature of 16858-01-8, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 16858-01-8, Name is Tris(2-pyridylmethyl)amine, molecular formula is C18H18N4. In a Conference Paper£¬once mentioned of 16858-01-8

Insights into the reactivity of epoxides as reducing agents in low-catalyst-concentration ATRP reactions

Modern atom transfer radical polymerization (ATRP) techniques employ relatively-low concentrations of copper complexes as the polymerization mediators. Typically, the catalyst is initially added in the higher oxidation (deactivating) state, so these systems require a reducing agent to generate in situ the lower oxidation state (activating) complex, able to react with an alkyl halide initiator, thereby initializing the polymerization. Epoxides can serve in this function and in this work, ethyl acrylate, methyl methacrylate, and styrene were homopolymerized in a well-controlled manner from an alkyl bromide initiator under low-catalyst-concentration ATRP conditions in the presence of an equimolar amount (vs monomer) of epoxides such as styrene oxide or phenyl glycidyl ether. A study on the free radical polymerization of ethyl acrylate, which occurred in the presence of styrene oxide and CuBr2 but only in the absence of radical traps/inhibitors, further demonstrated that the reduction of the deactivator by epoxides proceeds via the formation of a radical derived from an alkoxide anion originating from the epoxide.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Electric Literature of 16858-01-8, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 16858-01-8, in my other articles.

Reference£º
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI